An abnormal enlargement of the spleen is known as splenomegaly.
The spleen is enlarged in splenomegaly. The left upper quadrant (LUQ) of the human abdomen is where the spleen typically resides. One of the four cardinal signs of hypersplenism is splenomegaly, along with some reduction in the number of circulating blood cells, affecting granulocytes, erythrocytes, or platelets in any combination; a compensatory proliferative response in the bone marrow; and the possibility of splenectomy to correct these abnormalities. Splenomegaly is frequently linked to a rise in workload (such as in hemolytic anemias), which implies that it is a reaction to hyperfunction. Therefore, it is not unexpected that any disease process that involves the spleen destroying aberrant red blood cells is associated with splenomegaly.
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