Answer:
Europeans occupying most of the region and the Native Americans were forced to leave behind there lands in this process which caused the conflict between them.
Explanation:
The European settlers had a lot of weaponry with them and they had the will to acquire as much as land they can for there survival and development inside the region, as they had the Native Americans in there way in order to do so. And for that reason the European wanted to make some deals to legalize the whole process but the Native Americans were not yet ready to vacate these lands just for the cause of developing plantations and then eventually leading to development of industries. So, it caused great distress inside the region many of innocent free folk lost there lives in the battles that happened and some even lost many lands and riches to the Europeans in that time. However, the Native Americans were made to settle in some of the Southern states, and most of the Northern region was all occupied by the European settlers and there allies.
