An action potential arriving at the presynaptic terminal causes what to occur? multiple choice voltage-gated calcium ion channels open, and calcium ions diffuse into the cell. voltage-gated sodium ion channels open, and sodium ions diffuse into the cell. acetylcholine diffuses into the cell. ligand-gated sodium channels open, and sodium ions diffuse out of the cell. voltage-gated sodium ion channels open, and sodium ions diffuse out of the cell.