Respuesta :
Futile cycling is prevented as coenzyme A is used as the acetyl group anchor during each cycle of eukaryotic fatty acid degradation, which calls for multiple enzymes during eukaryotic fatty acid degradation.
Using FAD and NAD+ as oxidants, fatty acid degradation takes place in the mitochondrial matrix. Carnitine-mediated transport into the mitochondrial matrix is the final step in fatty acid degradation. In the cytosol, NADPH functions as a reductant for the production of fatty acids. Fatty acid synthase is a single multifunctional enzyme that catalyzes the reaction cycle in the synthesis of fatty acids.
It uses acyl carrier protein (ACP) as the hydrocarbon anchor and forms malonyl-CoA from acetyl-CoA and CO2 first. The production of malonyl-CoA, a substrate in the reaction cycle, is the rate-limiting step in the synthesis of fatty acids.
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