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Aristotle laid the philosophical groundwork for all subsequent discussions of elements, pure substances, and chemical combinations.

The nature of substances and their transformations were the main topics of Aristotle's theories, just like in contemporary chemistry. In On Generation and Corruption (De Generatione et Corruptione), Meteorology, and portions of Physics and On the Heavens, he provided the first systematic treatments of chemical theory (De Caelo).

Although he believed that some of them might be made of a single, pure component, Aristotle realized that the majority of common, tangible things are composed of several different substances. In order to identify a single substance, he needed to provide a purity standard. His standard was the homoeomerism of pure substances, which means that they are made up of similar components at all levels.

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