The cyclin/cyclin-dependent kinase pair that is active during the g1 phase of the cell cycle is cyclin E and Cdk2.
The cell cycle is regulated by controller molecules that either promote the process or stop it from advancing. The levels of the cyclin proteins (A, B, D, E) fluctuate throughout the cell cycle. Cyclins can only regulate the cell cycle when they form a complex with cyclin-dependent kinases.
Cyclins and cyclin-dependent kinases (Cdks) are responsible for promoting the cell cycle whereas negative regulation of the cell cycle is controlled by retinoblastoma protein (Rb), p53, and p21.
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