A CYP2D6 Ultrarapid Metabolizer (UM) would require a higher dose of a drug that is metabolized by CYP2D6 than a CYP2D6 Extensive Metabolizer (EM).
Ultrarapid Metabolizer is a drug metabolism phenotype that describes the ability to metabolize a drug at much faster rates than expected. Individuals who are UMs have an enzyme activity score greater than 2.5, often due to an increased copy number of the CYP2D6 gene.
Extensive metabolizers (EM) are the most common and are the type of people for which drugs are designed. It has the normal amount of medication at standard doses. However, up to 7% of Caucasians are poor metabolizers of drugs metabolized by the CYP2D6 enzyme.
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