A substance secreted by the vascular endothelial cells that can help to initiate fibrinolysis is the Tissue plasminogen activator.
Tissue plasminogen activator (tPA), also called alteplase which is a medication made of a protein that can dissolve blood clots. Human tPA is a glycoprotein produced mainly by vascular endothelial cells. It is a thrombolytic agent that will break down blood clots to restore blood flow to the ischemic region of the human brain, and it is the only FDA-approved medication available to treat ischemic stroke.
Fibrinolysis is a normal human body process. It prevents human blood clots, which occur naturally, from the growing and causing problems. A Primary fibrinolysis refers to the normal breakdown of clots.
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