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Aneuploidy is usually the result of an error in meiosis known as nondisjunction.

What is nondisjunction?

Nondisjunction is the aberrant distribution of chromosomes in the daughter nuclei that occurs when one or more pairs of homologous chromosomes or sister chromatids fail to separate correctly during nuclear division.

What takes place in a nondisjunction?

When nondisjunction occurs, the homologous or sister chromatids are drawn to one pole of the cell because the separation does not take place. Topoisomerase II, condensin, or separase inactivation can result in mitotic nondisjunction.

When is there a nondisjunction?

Nondisjunction errors can happen in either mitosis or meiosis II when sister chromatids fail to separate or in meiosis I when homologous chromosomes fail to separate.

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