Agonist: A substance that imitates the natural ligand for a receptor and activates it to cause a biological response is referred to as an agonist. Passive Diffusion is the most common way for pharmaceuticals to pass the cell membrane.
The most common NSAID, aspirin, increases the fluidity of lipid bilayers and causes structural and functional membrane disruption, including the suppression of raft formation by locally altering membrane organisation.
Polymyxin antibiotics, for example, have a typical structure consisting of a cyclic peptide with a long hydrophobic tail. By interacting with the phospholipids in the bacterial cell membrane, they disturb its structure.
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