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An increase in the volume of blood ejected from the heart, with no change in total peripheral resistance, would cause hyper-adrenergic response occurs in some illness situations, such as congestive heart failure, producing an increase in peripheral vascular resistance.

Peripheral vascular resistance is regulated locally by metabolites, and throughout time on a neuro-hormonal level, many distinct components may change, resulting in changes in peripheral vascular resistance.

What impact would a blood volume increase have on blood flow resistance?

Since the veins would extend further as a result of the increased capacity, resistance would decrease.

When your blood volume rises, your arteries and veins expand, resulting in higher blood pressure. Hypervolemia occurs when your body is unable to manage fluids adequately owing to poor kidney or liver function. Any increase in cardiac output (HR and/or SV), blood viscosity, or total peripheral resistance will result in an increase in blood pressure.

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