If repolarization is caused by the outward flow of k ions, raising external K+ to 400 mM should block repolarization
Repolarization is the process or act of restoring the polarized condition across the plasma membrane of a cell, e.g. nerve cell. During the normal resting state, the membrane potential is a negative value. But the negative membrane potential changes to positive following the depolarization of an action potential.
However, this shift from negative to positive value is only for a brief moment in time. The membrane potential returns to the resting membrane potential (which is negative value). The process or act of returning to a negative membrane potential is repolarization.
Repolarization occurs through the physiological mechanisms involving K+ channels, such as A-type channels, delayed rectifiers, and Ca2+-activated K+ channels. One such mechanism is when there is an efflux of K+ ions from the cell via the K+ channels in the plasma membrane. In general, the process of repolarization takes several milliseconds.
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