In the liver, gluconeogenesis converts lactate to glucose. If FBPase-1 is defective, lactate cannot enter the gluconeogenic pathway in hepatocytes, building up in the blood.
What is gluconeogenesis?
The process by which non-carbohydrate metabolites are converted into glucose is known as gluconeogenesis. The main gluconeogenic precursors include pyruvate and lactate, a few gluconeogenic amino acids, and glycerol, which is mostly produced during the breakdown of fat.
When food intake is inadequate or absent, new glucose is created from non-carbohydrate precursors. This process is known as gluconeogenesis. The management of acid-base balance, amino acid metabolism, and the creation of structural elements derived from carbohydrates are all dependent on it as well.
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