Factor concentrates and recombinant products with superior safety profiles are alternatives to cryoprecipitate, which also contains factor XIII, von Willebrand factor (vWF), and factor VIII.
If fibrinogen levels are not maintained using FFP, cryoprecipitate or fibrinogen concentrate may be recommended in cases of serious bleeding.
Treatment of the underlying illness is the cornerstone of DIC treatment. In patients with DIC, transfusion of platelets or plasma (components) should not be relied only on laboratory results and should generally be saved for patients who arrive with bleeding.
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