Atp is an activator of atcase while ctp is an inhibitor. how does the regulation of atcase by these two metabolites make sense in terms of its role in pyrimidine biosynthesis?

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darrengorman9113 darrengorman9113

18-08-2022
Biology

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Atp is an activator of atcase while ctp is an inhibitor. how does the regulation of atcase by these two metabolites make sense in terms of its role in pyrimidine biosynthesis?

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lhmarianateixeira lhmarianateixeira · Answer 1 · 2022-08-24T01:15:51+02:00

The regulation of atcase by these two metabolites make sense in terms of its role in pyrimidine biosynthesis because the CTP is a downstream product of the pyrimidine pathway and represents an example of feedback inhibition.

How does inhibition occur?

Irreversible inhibition occurs with the binding of the inhibitor covalently to the active site of the enzyme, while reversible inhibition occurs with the non-covalent binding of the inhibitor to the polypeptide chain of the enzyme.

The regulated by ATP, an ADP derivative called AMP, and citrate. ATP is a negative regulator , which makes sense: if there is already an abundance of ATP in the cell, there is no need to produce more through glycolysis.

See more about ATP at brainly.com/question/14637256

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