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If a cell is placed in a hypertonic solution, water will leave the cell, and the cell will shrink.

Crenation is a phenomenon which occurs when cells of animal origin are exposed to a hypertonic solution, meaning that the solution which bathes the cells has a high concentration of solutes. In crenation, the cells shrink and their shapes become distorted, often with a ruffled or scalloped edge.

When a red blood cell is placed in a hypertonic solution, it shrinks as water is drawn out of the cell and into the surrounding solution. If the same blood cell placed in a hypotonic solution, the blood cell grows in size. Blood cells in isotonic solutions do not shrink or swell.

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