In sickle cell anemia hemoglobin shows only on difference at position number at position 6 of the β globin chain.
People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin S. Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped. This is commonly called sickle cell anemia and is usually the most severe form of the disease.
The hemoglobin associated with sickle cell anemia causes red blood cells to become rigid, sticky and misshapen. People with sickle cell disease have lower hemoglobin levels, usually between 6–11 g/dL. The exact level may be different depending on the type of sickle cell disease and the person.
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