At concentrations of 0.1-1 g/mL. colchicine, a natural plant product, can cause the mitotic arrest of dividing cells at metaphase by disrupting the spindle apparatus. Colchicine
interferes with which of these cell functions during cell division?
A microtubule organization of spindle fibers
B DNA synthesis of spindle protein
C membrane transport of spindle fibers
D RNA synthesis of spindle protein