At concentrations of 0.1-1 g/mL. colchicine, a natural plant product, can cause the mitotic arrest of dividing cells at metaphase by disrupting the spindle apparatus. Colchicine
interferes with which of these cell functions during cell division?

A microtubule organization of spindle fibers

B DNA synthesis of spindle protein

C membrane transport of spindle fibers

D RNA synthesis of spindle protein