prostate cells usually require testosterone and other androgens to survive. but some prostate cancer cells thrive despite treatments that eliminate androgens. one hypothesis is that estrogen, often considered a female, may be activating genes normally controlled by an androgen in these cancer cells. desribe one or more experiments to test this hypothesis

One can check for the translation and transcription of genes of interest in the absence of androgens, one can check whether the estrogen is involved in the expression of oncogenic proteins of interest by depleting the estrogen, and one can also examine the existence of estrogen receptor complex in the prostrate cancer cells nuclei.

• One can check for the translation and transcription of genes of interest in the non-existence of androgens and if these genes are expressed then this suggests that apart from androgens other factors also affect their expression.

• One can deplete the estrogen from cancer cells and if the involvement of estrogen is there in the expression of oncogenic proteins of interest then its reduction will result in diminished multiplication rates in cancer cells.

• One can also test the existence of estrogen-receptor complex in the prostate cancer cells nuclei to confirm that estrogen is taking part in the regulation of gene expression.

Thus, various experiments can be conducted to check that whether the expression of genes controlled by the androgens under normal conditions are affected by the presence of estrogens in prostate cancer cells.

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