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What caused the first political parties to form? Early leaders were unable to agree on regional and economic differences. Differences between pro-war and anti-war leaders. It was President Washington's attempt to balance differences. It was a reaction to the those loyal to Britain and those against colonial rule.

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The correct answer is Early leaders were unable to agree on regional and economic differences.

They differed in the opinion on who should have more power, the federation or the states, and on which system should the economy be based. They were called federalists and anti-federalists.

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