how to differentiate [tex]f(x)= \frac{5}{x} +1[/tex]

find f'(x) and f'(2) and f'(4)
I know that to differentiate you do
[tex] \lim_{changex \to 0} \frac{f(x+changex)-f(x)}{changex} [/tex] where changex=Δx
but I'm stuck
ples help