You just need to plug those expressions inside the formula: it doesn't matter if they're expressions involving a variable instead of plain numbers: the formula becomes
[tex] V = \pi (x+8)^2(2x+3) [/tex]
If you want, you can simplify it by expanding the square and then multiply the two parenthesis:
[tex] V = \pi (x^2+16x+64)(2x+3) = \pi (2 x^3 + 35 x^2 + 176 x + 192) [/tex]