This
is because mitosis does not change the zygosity
of the cell but only replicates the genetic material before separation o daughter cells.
However, meiosis halves the zygosity of the parent cell (by separating
homologous sister chromosomes) hence the daughter cells must have equal numbers
of chromosomes (n). Meiosis will, therefore, be difficult in mule due to the abnormal
number of chromosomes (odd numbered) hence resulting in the unequal division of
the chromosomes during meiosis during the making of sperm or egg cells.