What is the most appropriate next step in the management of this patient with a 2.5 cm lesion on her vulva that returned as vulvar intraepithelial neoplasia grade 3 (VIN 3)?
1) Imiquimod (Aldara) treatment
2) Trichloroacetic acid (TCA) treatment
3) Wide local excision
4) Cryotherapy
5) Radical vulvectomy